| sas7bput | SAS Permanent Utility |
| sas7butl | SAS Utility |
| sass | Sass Indented Syntax Data |
| sb | Laird smartBASIC Source Code |
| sbr | Visual Studio Source Browser Data |
| sbsx | Microsoft Storyboard Shapes File |
| sbt | SBT Build Definition |
| sc | Esterel Unsorted Circuit Code |
| sca | Scala InfoChannel Script |
| scala | Scala Source Code |
| scat | RealView Scatter-loading Data |
| scb | Scala InfoChannel Published Script |
| scc | Microsoft Visual SourceSafe File |
| sce | Scilab Script |
| scex | Modgen Scenarion Data |
| sci | Scilab Macro Definitions |
| scm | Scheme Source Code |
| scn | Godot Engine Binary Scene Data |
| scpp | TestComplete C++Script Unit |
| scpt | AppleScript Script |
| scptd | AppleScript Script Bundle |
| scq | SAS Sequential Access Data |
| scr | µVision Linker Scatter Loader |
| screen | Indigo Studio Screen Data |
| scriptsuite | AppleScript Script Suite |
| scro | Amira Script Object |
| scss | SASS CSS File |
| sct | µVision Linker Control Data |
| sct | Script Component File |
| sct | Visual FoxPro Form Memo |
| scurl | Curl Source Code |
| scx | Microsoft Visual FoxPro Form |
| sdef | AppleScript Dictionary Document |
| sdff | IBM SDK for Java System Dump |
| sdm | System Definition Model |