| spr | Sega Dreamcast VR Sprite Data |
| spreporter | Mac OS X System Profiler Reporter Data |
| sprf | Manip Saved Proof File |
| sps | Oracle Package Specification |
| sps | SPSS Syntax File |
| sps | SyncBack Exported Profile |
| spsd | eXtendable Wad Editor SPSD Data |
| spsm | Substance Painter Smart Material Data |
| spsx | SPSS Password Protected Data |
| spt | EGSEING Spectrum Mode Data |
| spt | SpeedTree Tree Data |
| spub | BeLight Disc Cover Data |
| spud | iGO Primo SpeedCam Database Update |
| spumux | DVDAuthor XML Subtitle Data |
| spv | Spekwin32 Data |
| spv | SPSS Output Document |
| spvchain | MultiBit Locally Stored Blockchain |
| spx | Mac OS X System Profiler XML Report |
| sq3 | oml2-server Database |
| sq3 | SQLite 3 Database |
| sq7 | Daktronics Venus 7000 Sequence Data |
| sqb | SQL Backup SQL Server Backup |
| sqd | DNASTAR SeqMan Document |
| sqd | FidoNet Squish Data |
| sqd | Sysquake SQ Data |
| sqg | SeQuence Graph Data |
| sqi | FidoNet Squish Index Data |
| sql | FidoNet Squish Lastread Storage |
| sql | SQL Script |
| sqlite | SQLite Database |
| sqlite | WhatsApp Messenger for iPhone Database |
| sqlite-shm | SQLite Shared Memory Data |
| sqlite-wal | SQLite Quasi-persistent Data |
| sqlite2 | SQLite 2.0 Database |
| sqlite3 | SQLite 3 Database |
