| sci | Scilab Macro Definitions |
| scm | Scheme Source Code |
| scn | Godot Engine Binary Scene Data |
| scpp | TestComplete C++Script Unit |
| scpt | AppleScript Script |
| scptd | AppleScript Script Bundle |
| scq | SAS 6 Catalog Data |
| scr | µVision Linker Scatter Loader |
| screen | Indigo Studio Screen Data |
| scriptsuite | AppleScript Script Suite |
| scriptterminology | AppleScript Terminology Data |
| scro | Amira Script Object |
| scss | SASS CSS File |
| sct | Script Component File |
| sct | Visual FoxPro Form Memo |
| sct | µVision Linker Control Data |
| scuf | Simple Scaffolder Template Data |
| scurl | Curl Source Code |
| scx | Microsoft Visual FoxPro Form |
| sdcl | SharpDevelop Control Library |
| sdef | AppleScript Dictionary Document |
| sdff | IBM SDK for Java System Dump |
| sdm | System Definition Model |
| sdq | SAS Data |
| sdt | IBM Rational SDL Suite Data |
| se | Shuttle Source |
| seam | Seam Framework Java Servlet |
| seestyle | Coda Style Sheet |
| seexpl | Spec Explorer Data |
| sem | Alpha Five Set Object |
| servoy | Servoy Archive |
| set | Alpha Five Set Data Dictionary |
| sex | Alpha Five Set Index |
| sexi | Alpha Five Set Index |
| sfd | µVision Intermediary Pseudo-XML Data |
