| spd | SPSD/M Database |
| spd | Windows Server Security Policy Database |
| spda | Surveyor PDA Detector Data |
| spdata | Microsoft SharePoint Project Data |
| spdb | iGO Primo SpeedCam Database |
| spe | SPSS Extension |
| speccy | Speccy Snapshot Data |
| spentry | Spartan Entry Database |
| spex | SPEX Data |
| spf | SQR Portable Format |
| spfs | Spider File Storage |
| spg | SG TCP Optimizer Backup |
| sph | Ribbons Sphere Definition |
| sph | MikuMikuDance Sphere Multiplied Map |
| spinput | Spartan Spinput Format File |
| spk | SPARKvue v1.0 Data |
| spk2 | SPARKvue v2.0 Data |
| spl | AkAbak Simulation Data |
| spl | Windows Spool Data |
| spl | Abacom sPlan Components Database |
| spl7 | Abacom sPlan 7 Circuit Diagram |
| splan | SPSS Statistics Simulation Plan |
| splf | SecureZIP Spool File |
| spm | Nanoeducator File |
| spmo | SpeedView Meta Object |
| spn | PC-SPAN SPAN Data |
| spn | GSSHA Storm Pipe Network |
| spo | SPSS Statistical Output |
| spo | SPOCK External Objects Data |
| spom | FEARLUS Stochastic Patch Occupancy Model |
| spq | SPSS Saved ODBC Query |
| spr | ArchiCAD Slab Properties |
| sprf | Manip Saved Proof File |
| sps | SPSS Syntax File |
| spub | BeLight Disc Cover Data |
