| scml | Spriter Data |
| scmt | GXS Application Integrator XML Constraint |
| scn | AutoDesk Softimage Scene |
| scn | BPM Studio Scan Data |
| scn | Kermit Screen Dump |
| scn | LabPower Junior Data |
| scn | Orbiter Scenario Data |
| scn | PCAnywhere Screenshot Data |
| scn | Pinnacle Studio Scene Data |
| scn | RTrace Ray Tracer Scene Data |
| scn | TD Scan Data |
| scn0 | Nintendo Wii Texture Animation Data |
| sco | ASD TerraSpec Data |
| sco | Microsoft IIS Schema Backup |
| sco | Sibelius Scorch Data |
| score | Learning Score Data |
| scp | Palm OS Configuration Data |
| scp | SCP-ECG Data |
| scpb | Survivorship Care Plan Builder Data |
| scprt | Surfcam 3D Format Data |
| scr | BricsCAD Script |
| scr | Image-Pro Plus Script |
| scr | Movie Master Screenplay Data |
| scr | Procomm Plus Screen Snapshot |
| scr | STATISTICA Scrollsheet Data |
| scrate | Serato DJ Smart Crate Data |
| screenrec | ScreenRec Recording Data |
| screstorelog | Spring Cleaning Restore Log |
| scresults | Spring Cleaning Results Data |
| script | SitePad Pro Script |
| script | XtalView Xfit Script |
| scriptlibrary | Corel Painter Script Library |
| scs | ASiC Simple Container |
| scs | CADint PCB Data |
| scs | Prism3D Data |
