| sbs | SWAT HRU Output Data |
| sbstore | Mozilla Firefox Safebrowsing Database |
| sbw | US Treasury Savings Bonds Wizard Data |
| sc | IBM EMMS Secure Container |
| sc0 | Structure Survey Editor Profile |
| sc2 | SAS Catalog |
| sc7 | SAS Catalog |
| scad | OpenSCAD Script |
| sccef | StreamCryptor Chunked Encrypted Dat |
| sccm | System Center Configuration Manager file |
| sccs | SCCS Data |
| scd | Intuit TurboTax Tax Line Items |
| scdata | RSSIM Scene Reflectance Data |
| sce | YASARA Scene |
| scel | Sogou Pinyin Cell Dictionary Data |
| scenario | Yarn Data |
| scene | VCollab Pro Scene Data |
| scexcludb | Spring Cleaning Exclusions Data |
| scgc | myPM SCG Classic Data |
| scgp | myPM SCG Pro Data |
| scgs | myPM SCG Starter Data |
| sch | Microsoft SQL Server Data Replication Schema |
| sch | TINA Schematic Data |
| schakal | SCHAKAL Chemical Modeller Input file |
| schd | Microsoft Excel Schedule Data |
| schdoc | Altium Designer Schematic File |
| schemas | GNOME GConf Schema Definition |
| schk | SortSite Site Data |
| schlib | Altium Designer Schematic Library |
| scjournal | SpaceClaim Journal Data |
| scl | Sibelius Scale Diagram Library |
| scml | Spriter Data |
| scmt | GXS Application Integrator XML Constraint |
| scn | AutoDesk Softimage Scene |
| scn | LabPower Junior Data |