| spc | Thermo Scientific SPC File |
| spc | Zemax Spectrum Source Data |
| spcmd | Stereoscopic Player Commands Data |
| spcolor | Microsoft SharePoint Color Palette Data |
| spd | Form Z Suspended Rendering FIle |
| spd | SpecTRM Specification |
| spd | SPSD/M Database |
| spd | SPSS Custom Dialog Data |
| spd | Windows Server Security Policy Database |
| spda | Surveyor PDA Detector Data |
| spdata | Microsoft SharePoint Project Data |
| spdb | iGO Primo SpeedCam Database |
| spdc | SAS SPD Data Set |
| spdesignasmx | Microsoft SharePoint Designer ASMX Data |
| spdesignbar | Microsoft SharePoint Designer Bar Data |
| spdesignbot | Microsoft SharePoint Designer Bottom Data |
| spdesigncss | Microsoft SharePoint Designer CSS Data |
| spdesignhtml | Microsoft SharePoint Designer HTML Data |
| spdesignjs | Microsoft SharePoint Designer JS Data |
| spdesignlist | Microsoft SharePoint Designer List Data |
| spdesignshtm | Microsoft SharePoint Designer SHTML Data |
| spdesignskin | Microsoft SharePoint Designer Skin Data |
| spdesigntxt | Microsoft SharePoint Designer Text Data |
| spdesignxml | Microsoft SharePoint Designer XML Data |
| spdesignxslt | Microsoft SharePoint Designer XSLT Data |
| spdkey | Spyware Process Detector Key Data |
| spdnv | Spreadtrum NV Backup |
| spe | SPSS Extension |
| speccy | Speccy Snapshot Data |
| spef | Standard Parasitic Exchange Format |
| spentry | Spartan Entry Database |
| spex | SPEX Data |
| spexp | Substance Painter Export Preset Data |
| spf | SQR Portable Format |
| spf | StruCAD 3D Model |
