| ecms | ECMerge Merge Status Data |
| ecmul | WinZip Registration Data |
| ecn | Electrochemical Noise Data |
| eco | EccoPro Database |
| ecp | Ettercap Packet Log |
| ecr | Ecrypt Encrypted File |
| ecryptfs | eCryptfs Data |
| ecu | TunerPro ECU Configuration |
| ecv | NETSCAN Vertex Search Results |
| ecx | EccoPro Corrupted Database |
| ed2 | CHARMM ED2 Data |
| ed3 | CHARMM ED3 Data |
| edat | E-Prime E-DataAid 1.x File |
| edat2 | E-Prime E-DataAid 2.x File |
| edb | Microsoft Exchange Database |
| edf | ESRF Data Format |
| edf | Altera EDIF Input File |
| edgx | Microvellum Edgeband File |
| edh | HRV Edit Data |
| edh2 | HRV Edit Data |
| edi | GROMACS Essential Dynamics Information |
| edi | ENVI-met Information File |
| edl | Edit Decision List |
| edm | PTC Creo Wire EDM Data |
| edn | Altera EDIF Input File |
| edn | Adobe DRM Activation Key |
| edo | GROMACS Essential Dynamics Output |
| edp | Micro Focus Extra! Display Session |
| edpi | ExamDiff Pro Session Data |
| edr | GROMACS Portable Energy Data |
| edr | Embird Color Palette Data |
| eds | Electronic Data Sheets |
| edt | ENVI-met Data File |
| edz | PTC Creo View ECAD Package |
| ee | CN3 Extended Ephemeris Data |