| snb | S-Note Data |
| snbkp | S Memo Backup |
| sne | Spectronaut Experiments Data |
| snes | SNES ROM Image |
| snf | Starry Night Data |
| snip | Microsoft Windows Snipping Tool Snip Data |
| snl | EGrid32 Form Snippet |
| snm | Netscape Mail Index |
| snmm | Samsung Note Data |
| snn | STATISTICA v7 Neural Networks File |
| snoop | Snoop Verbose Trace File |
| snp | Altair FEKO POSTFEKO Touchstone Data |
| snp | ComputerEyes Output Animation Data |
| snp | GenePattern SNP Data |
| snp | Oracle Database Snapshot |
| snr | Mail.dat Seed Name File |
| sns | Save-N-Sync Profile |
| snx | ZX Spectrum Emulator Snapshot Extended |
| soa | Sage MAS 90 Data |
| sod | BiRT Spreadsheet Object Design File |
| soepsx | Player Studio Viewer Data |
| sof | Altera SRAM Object File |
| soft | Autodesk Maya FCheck Tool Data |
| soi | BiRT Spreadsheet Object Instance File |
| sok | Sokoban YASC Game Data |
| sol | Adobe Flash Player Shared Object |
| sol | AMPL Solution File |
| sol | AquaCrop Soil Profile Data |
| sol | Canoco Analysis Data |
| sol | PATCHMASTER Solution File |
| sol | SWAT Soil Input Data |
| solr | Apache SOLR Data |
| songs | MediaShout Song Library |
| sopcinfo | SOPC Builder Information |
| sor | Adobe Flash Media Server Client Side Shared Object |
