| scl | Sibelius Scale Diagram Library |
| scml | Spriter Data |
| scmt | GXS Application Integrator XML Constraint |
| scn | AutoDesk Softimage Scene |
| scn | LabPower Junior Data |
| scn | Orbiter Scenario Data |
| scn | PCAnywhere Screenshot Data |
| scn | RTrace Ray Tracer Scene Data |
| scn0 | Nintendo Wii Texture Animation Data |
| sco | ASD TerraSpec Data |
| sco | Microsoft IIS Schema Backup |
| sco | Sibelius Scorch Data |
| scp | SCP-ECG Data |
| scpb | Survivorship Care Plan Builder Data |
| scprt | Surfcam 3D Format Data |
| scr | Procomm Plus Screen Snapshot |
| scr | STATISTICA Scrollsheet Data |
| scrate | Serato DJ Smart Crate Data |
| screstorelog | Spring Cleaning Restore Log |
| scresults | Spring Cleaning Results Data |
| script | XtalView Xfit Script |
| scs | ScreenCam Script |
| scs | Siemens Mobil Phone Color Skin |
| scs | StuffIt Saved File List |
| scsf | SEE Finance Data |
| scssc | Sass Compiled Data |
| sct | Carlson 2016 Overlay Section Data |
| sct | SPSS Template Data |
| sct01 | SAS Catalog Data |
| sctid | RSA SecurID Software Certficate Import Data |
| scvd | µVision System Component Viewer Description |
| scy | ReaGeniX License Data |
| sd | MDL Molfile Data |
| sd | STK Satellite Database Main File |
| sd2 | SAS Data Set |
