| ecd | Abbyy FineReader Compiled Dictionary |
| ecfg | ArcGIS Registry Configuration Archive |
| ecg | Electrocardiography Data |
| ech | EasyChem Save |
| eci | Ettercap Info Log |
| ecl | Mass Mailing News E-Campaign List |
| ecml | EpiCollect Markup Language Document |
| ecml | QuickBooks License Data |
| ecms | ECMerge Merge Status Data |
| ecmul | WinZip Registration Data |
| ecn | Electrochemical Noise Data |
| eco | EccoPro Database |
| ecorediag | Kermeta Ecore Diagram Information |
| ecp | Ettercap Packet Log |
| ecr | Ecrypt Encrypted File |
| ecryptfs | eCryptfs Data |
| ecu | TunerPro ECU Configuration |
| ecv | NETSCAN Vertex Search Results |
| ecx | EccoPro Corrupted Database |
| ed2 | CHARMM ED2 Data |
| ed3 | CHARMM ED3 Data |
| edat | E-Prime E-DataAid 1.x File |
| edat2 | E-Prime E-DataAid 2.x File |
| edb | Microsoft Exchange Database |
| edf | Altera EDIF Input File |
| edf | ESRF Data Format |
| edf2 | EEGLAB Data Set |
| edgx | Microvellum Edgeband File |
| edh | HRV Edit Data |
| edh2 | HRV Edit Data |
| edi | ENVI-met Information File |
| edi | GROMACS Essential Dynamics Information |
| editma | Autodesk Maya 3D Offline ASCII Scene |
| editmb | Autodesk Maya 3D Offline Binary Scene |
| edl | Edit Decision List |