| em | PCEM Electromask Data |
| email | Microsoft Outlook Express Junkmail Data |
| emap | Genetica Environment Map |
| emar | Emissions Model ASCII Record |
| emb | Wilcom Embroidery Data |
| embl | ENA EMBL Sequence |
| embr | Emissions Model Binary Record |
| emc | Striata Encrypted E-mail Attachment |
| emdl | AutoDesk Softimage Export Model |
| emf | EES Macro Data |
| emg | Delsys EMGworks Data |
| emi | WeintekHMI EasyBuilder 8000 EMI File |
| emk | PCEM Electromask Data |
| emlx | Apple Mail Message |
| emlxpart | Apple Mail Message Attachment Data |
| emm | EARS Mail Merge Definition |
| emn | Pro/ENGINEER ECAD IDF File |
| emo | Miranda IM Emotions |
| emrg | E-Prime E-Merge 1.x File |
| emrg2 | E-Prime E-Merge 2.x File |
| ems | eMachineShop Data |
| emu | EMU Speech Database |
| emu | IRMA 3270 Emulation Setup Data |
| emulecollection | eMule Data |
| enb | EverNote Database |
| enc | Uuencoded Data |
| encr | TI bqEASY Data Flash RAW |
| end | Tinker End File |
| ene | GROMACS Binary Energy File |
| enex | EverNote XML Archive |
| enf | EndNote Filter Data |
| enfpack | Enfocus PitStop Package |
| enh | CRiSP Harvest Model Enhancement File |
| enk | Sybase Enterprise Portal Security Key |
| enl | EndNote Library Data |