| edl | Edit Decision List |
| edm | PTC Creo Wire EDM Data |
| edn | Altera EDIF Input File |
| edn | Adobe DRM Activation Key |
| edo | GROMACS Essential Dynamics Output |
| edp | Micro Focus Extra! Display Session |
| edpi | ExamDiff Pro Session Data |
| edr | GROMACS Portable Energy Data |
| edr | Embird Color Palette Data |
| eds | Electronic Data Sheets |
| edt | ENVI-met Data File |
| edz | PTC Creo View ECAD Package |
| ee | CN3 Extended Ephemeris Data |
| eea | DrugPak Encrypted Email Attachment |
| eeg | Neuroscan EEG Data |
| eek | Arachne Network-Enabled Script |
| eel | Atmosphere IoT Embedded Element Library |
| eem | Emonitor Extraction Manager Data |
| eep | EEPROM Data |
| eep | Project64 Saved Game Data |
| eet | Enlightenment EET Data File |
| eex | Oracle BI Discoverer EUL Export |
| ef | Diploma Exam File |
| efb | EVS Binary Compressed Field Data |
| efcl | Hytera CPS Encrypted Feature License Data |
| efd | EARS Filter Definition |
| eff | EVS Field Data |
| effect | Serato DJ Audio Effect Data |
| efg | Gambit Extensive Game Format File |
| efif | Picsel eFIF Data |
| efl | Encryptafile Encrypted File |
| efo | EASE Focus Data File |
| efrm | 4D Database for Mac Apply Formula Data |
| efz | EVS GZip Compressed Field Data |
| eg | ElmerGrid Command File |