| ebts | Electronic Biometric Transmission Standard |
| ebv | Ash Ware Enhanced Behaviour Data |
| ebw | Encyclopaedia Britannica Database |
| ec0 | MetroCount Traffic Data |
| ec8 | Cashflow Manager v8 Export File |
| ecb | EccoPro Database Backup |
| ecc | Dvdisaster Error Correction Data |
| ecd | Abbyy FineReader Compiled Dictionary |
| ecg | Electrocardiography Data |
| ech | EasyChem Save |
| eci | Ettercap Info Log |
| ecl | Mass Mailing News E-Campaign List |
| ecml | EpiCollect Markup Language Document |
| ecml | QuickBooks License Data |
| ecmul | WinZip Registration Data |
| ecn | Electrochemical Noise Data |
| eco | EccoPro Database |
| ecp | Ettercap Packet Log |
| ecr | Ecrypt Encrypted File |
| ecryptfs | eCryptfs Data |
| ecu | TunerPro ECU Configuration |
| ecv | NETSCAN Vertex Search Results |
| ecx | EccoPro Corrupted Database |
| ed2 | CHARMM ED2 Data |
| ed3 | CHARMM ED3 Data |
| edat | E-Prime E-DataAid 1.x File |
| edat2 | E-Prime E-DataAid 2.x File |
| edb | Microsoft Exchange Database |
| edf | Altera EDIF Input File |
| edf | ESRF Data Format |
| edgx | Microvellum Edgeband File |
| edh | HRV Edit Data |
| edh2 | HRV Edit Data |
| edi | GROMACS Essential Dynamics Information |
| edi | ENVI-met Information File |