| epc | EXPACS-V Document |
| epd | Extended Position Description File |
| epf | Microsoft Exchange Security Settings |
| epg | DynaVox Page File |
| eph | SiRFDemo GPS Ephemeris File |
| epim | EssentialPIM Database |
| epitask | Telestream Episode Task |
| epk | E-Prime E-Studio 1.x Package File |
| epk2 | E-Prime E-Studio 2.x Package File |
| epl | Echoview 3D Polyline Data |
| epo | Android GPS Extended Prediction Orbit Data |
| ept | Casio WK-1800 Converted Pattern |
| ept | EES Plot Template |
| epw | EnergyPlus Weather Data |
| eqa | WinISI III Equation Data |
| eqb | eSignal Quote Board Data |
| eqbak | EQATEC Profiler Data |
| eqd | EquineMax Data |
| eqd | Microsoft SQL English Query Domain Data |
| eqf | Equalization Filters File |
| eqlog | EQATEC Profiler Log |
| eqn | KaleidaGraph Macro |
| eqt | ReliaSoft Weibull++ Data |
| equ | AstroDigital.Net Equipment File |
| eqv | IDL EQV Equation Data |
| eqw | SPEFO Equivalent Widths Data |
| er | E-Cell 2 Rule Data |
| era | Electronic Remittance Advice Data |
| erdplus | ERDPlus Database Model |
| ere | EagleEyeOS Report |
| erg | CompuTrainer Ergometer Test |
| ero | eLibrary Reader Object |
| err | Error Log File |
| ersx | Eraser Scheduled Task List |
| es | E-Prime E-Studio 1.x Experiment File |