| ebb | Empower Business Bulletin Data |
| ebb | The Bat! Encrypted Message Archive |
| ebcdic | EBCDIC Encoded Data |
| ebd | IBIS Electrical Board Description |
| ebf | Efficient Binary Format Data |
| ebi | The Bat! Encrypted Message Index |
| ebim | Extended Building Information Model |
| ebnf | Extended Backus-Naur Form |
| ebsx | Bid Express Proposal Data |
| ebts | Electronic Biometric Transmission Standard |
| ebv | Ash Ware Enhanced Behaviour Data |
| ebw | Encyclopaedia Britannica Database |
| ec0 | MetroCount Traffic Data |
| ec8 | Cashflow Manager v8 Export File |
| ecb | EccoPro Database Backup |
| ecc | Dvdisaster Error Correction Data |
| ecd | Abbyy FineReader Compiled Dictionary |
| ecg | Electrocardiography Data |
| ech | EasyChem Save |
| eci | Ettercap Info Log |
| ecl | Mass Mailing News E-Campaign List |
| ecml | EpiCollect Markup Language Document |
| ecml | QuickBooks License Data |
| ecn | Electrochemical Noise Data |
| eco | EccoPro Database |
| ecp | Ettercap Packet Log |
| ecr | Ecrypt Encrypted File |
| ecu | TunerPro ECU Configuration |
| ecv | NETSCAN Vertex Search Results |
| ecx | EccoPro Corrupted Database |
| ed2 | CHARMM ED2 Data |
| ed3 | CHARMM ED3 Data |
| edat | E-Prime E-DataAid 1.x File |
| edat2 | E-Prime E-DataAid 2.x File |
| edb | Microsoft Exchange Database |