| spmsk | Substance Painter Smart Mask Data |
| spn | Corel WordPerfect Distribution Definition |
| spn | GSSHA Storm Pipe Network |
| spn | PC-SPAN SPAN Data |
| spo | SPOCK External Objects Data |
| spo | SPSS Statistical Output |
| spom | FEARLUS Stochastic Patch Occupancy Model |
| spool | Ubisoft Game Launcher Spool Data |
| spp | Scrapbook Factory Data |
| spp | SPSS Windows Production Mode Data |
| sppr | Substance Painter Presets Data |
| spq | SPSS Saved ODBC Query |
| spr | ArchiCAD Slab Properties |
| spr | ConQuest Exported Spreadsheet |
| spr | NeroMIX SPR Data |
| spr | Sega Dreamcast VR Sprite Data |
| spreporter | Mac OS X System Profiler Reporter Data |
| sprf | Manip Saved Proof File |
| sps | Oracle Package Specification |
| sps | SPSS Syntax File |
| sps | SyncBack Exported Profile |
| spsd | eXtendable Wad Editor SPSD Data |
| spsm | Substance Painter Smart Material Data |
| spsx | SPSS Password Protected Data |
| spt | EGSEING Spectrum Mode Data |
| spt | SpeedTree Tree Data |
| spub | BeLight Disc Cover Data |
| spud | iGO Primo SpeedCam Database Update |
| spumux | DVDAuthor XML Subtitle Data |
| spv | Spekwin32 Data |
| spv | SPSS Output Document |
| spvchain | MultiBit Locally Stored Blockchain |
| spx | Mac OS X System Profiler XML Report |
| sq3 | oml2-server Database |
| sq3 | SQLite 3 Database |
