| sr8 | RECOIL Data |
| sra | Sequence Read Archive |
| srd | Summary Record Database |
| srec | Motorola S-record Data |
| srf | BrainVoyager QX Surface Data |
| srfl | SurfLogger Log |
| srfmap | Terragen Surface Map Data |
| srg | Ketron Single Registration |
| srh | BMC Remedy AR System Server Saved Search |
| srl | ASwin Shared Database |
| srm | SNES Save State File |
| srn | SCIRun Network File |
| sro | ATIS SR Output File |
| srp | MotionTracking Object Search Parameters Data |
| srr | Xilinx ISE Synplicity Report |
| srs | Microsoft Outlook Send/Receive Settings |
| srx | SPARQL Query Results XML |
| ss | Ribbons Secondary Structure |
| ss1 | Cygnus MK Data Logger Single Record |
| ss3 | SKM Power Tools PPE Table Information |
| ss6 | SKM Power Tools SAB Table information |
| ssd | Stardock WindowBlinds Skin Filelist |
| ssd | StatView DataSet Transfer |
| ssdf | Simple Structured Data Format File |
| ssdl | Sonicfire Pro Music |
| sse | StrataSearch Data File |
| ssfn | Steam Guard Data |
| ssg | Investor's Toolkit Data |
| ssi | SAP Business Objects Shared Security Information File |
| ssii | ProReveal Test Data File |
| ssj | STAR Splice Junction Data |
| ssleay | SSLeay Data |
| sslf | HLSW Shared Server List |
| ssm | BrainVoyager QX SSM Data |
| ssml | Speech Synthesis Markup Language Source Code |