| sic | Intuit Quicken Order Data |
| sic | Sick Submitter Data File |
| sid | Steam Game Backup Data |
| sidb | iTunes Authorization Data File |
| sidd | iTunes Authorization Data File |
| sidn | iTunes Authorization Data File |
| sie | SIE Data |
| sif | ElmerSolver Command File |
| sif | Cytoscape Simple Interaction Format File |
| sif | KilnView Log Signature |
| siff | Scene Interchange File Format Data |
| sig | Crestron Test Manager Signal Data |
| sig | Powersim Studio Simulation Game |
| sign | GNU Privacy Guard Signature Data |
| silo | MeshTV Data |
| sim | CARE-S InfoWorks Simulation Parameters Data |
| sim | Steam Game Backup Metadata |
| sim | Simile Model |
| simmodel | Altium Designer Simulation Model |
| simodel | Altium Designer Signal Integrity Model |
| sin | Xperia X10 Phone SIN Firmware |
| sip | Powersim Studio Model |
| siq | Tektronics RSA306 IQ Streaming Data |
| siqd | Tektronics RSA306 SIQ Data |
| siqh | Tektronics RSA306 SIQ Header |
| sir | Powersim Studio Simulation Run File |
| sis | Steam Game Backup Info |
| sit | Epson Projector Basic Scenario Data |
| sit | PTC Creo Site Parameter Data |
| site | Sitescooper Sites Data |
| siw | ANSYS SIwave Data |
| sjd | Scrapbook Factory Journal Data |
| sjf | SCAPS SAM JobFile Format |
| sjx | Seljax Estimating and 3D Design Data |
| sk | Safari History Index |