| sbox | sBOX Meta-file |
| sbp | OpenSBP CNC Program |
| sbq | Superbase Quick Report File |
| sbs | SpyBot Search and Destroy Include |
| sbstore | Mozilla Firefox Safebrowsing Database |
| sbw | US Treasury Savings Bonds Wizard Data |
| sc0 | Structure Survey Editor Profile |
| sc2 | SAS Catalog |
| sc7 | SAS Catalog |
| scad | OpenSCAD Script |
| scd | Intuit TurboTax Tax Line Items |
| scdata | RSSIM Scene Reflectance Data |
| sce | YASARA Scene |
| scenario | Yarn Data |
| scene | VCollab Pro Scene Data |
| sch | Microsoft SQL Server Data Replication Schema |
| sch | TINA Schematic Data |
| schdoc | Altium Designer Schematic File |
| schemas | GNOME GConf Schema Definition |
| schk | SortSite Site Data |
| schlib | Altium Designer Schematic Library |
| scml | Spriter Data |
| scmt | GXS Application Integrator XML Constraint |
| scn | AutoDesk Softimage Scene |
| sco | Microsoft IIS Schema Backup |
| scp | SCP-ECG Data |
| scpb | Survivorship Care Plan Builder Data |
| scprt | Surfcam 3D Format Data |
| scs | Siemens Mobil Phone Color Skin |
| scs | StuffIt Saved File List |
| scssc | Sass Compiled Data |
| sctid | RSA SecurID Software Certficate Import Data |
| scy | ReaGeniX License Data |
| sd | STK Satellite Database Main File |
| sd2 | SAS Data Set |
